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Whilst small-depend MBL hardly ever progresses to CLL, substantial-rely MBL progresses to CLL necessitating therapy in a rate of 1% to 2% a year. Substantial-count MBL is distinguished from Rai 0 CLL based on whether or not the B-mobile depend is earlier mentioned or underneath five × 109/L. While people today with each superior-depend MBL and CLL